Brain Tumors, Symptoms and Causes
The Brain Tumor Center at North Shore-LIJ Health System's Cushing Neuroscience Institute offers a multidisciplinary program that focuses on the management of benign and malignant brain tumors. Our center is directed by Dr. Michael Schulder, an internationally recognized authority on the treatment of brain and skull base neoplasms (tumors). Our services include comprehensive diagnosis and multi-modality treatments, leading-edge research and brain tumor outreach education programs for healthcare professionals and our community.
As one of the country's leading brain tumor centers, our specialists treat the following benign and malignant brain tumors:
- Astrocytomas – the most common type of gliomas (malignant brain tumors). Astrocytomas are most commonly found in the cerebrum, the main part of the brain
- Meningiomas – predominantly benign slow-growing tumors that account for about 20 percent of primary brain tumors
- Pituitary Tumors – Most pituitary gland tumors are adenomas (benign brain tumors). Adenomas do not spread outside the skull and usually remain confined to the pituitary gland or in tissue near it.
- Metastatic Brain Tumors – malignant brain tumors that originate from cancers in other parts of the body
- Brainstem Gliomas – malignant tumors located in the brain stem where the spinal cord connects to the brain just above the back of the neck
- Ependymomas – malignant tumors in the epithelial layers of the brain
- Glioblastoma Multiforme – the most aggressive of malignant brain tumors
- Medulloblastoma – the most common type of childhood brain cancer
- Oligodendrogliomas – malignant brain tumors that arise from brain tissue
- Schwannomas – benign brain tumors on the eighth cranial nerve
Multidisciplinary Care and Treatment
Staffed by a team of neurosurgeons, neuro-oncologists, neurologists, neu-radiologists and neuro-pathologists, the Brain Tumor Center fosters a unique collaboration among the departments of Neurosurgery, Neurology and Medical and Radiation Oncology. Our accomplished team works together with the common goal of providing the most up-to-date evaluations and personalized treatments for patients with brain tumors.
The Brain Tumor Center's areas of expertise include these treatments:
- Stereotactic Neurosurgery – a form of minimally invasive surgery using radiation
- Skull Base Surgery – This intricate surgery requires high-level skills to operate safely in the most complex area of the body where nerves, arteries and sensing organs are densely concentrated.
- Minimally Invasive Endoscopic Surgery – This surgical technique inserts a thin, lighted instrument (endoscope) into a very small incision. It is sometimes an option to the traditional open surgery method which involves larger incisions.
- Stereotactic Radiosurgery – a form of radiation therapy that focuses high-powered x-rays on a small area of the brain without affecting adjacent healthy tissue
These surgical techniques are spurred on by the Brain Tumor Center's research, which addresses important fundamental and clinical questions about brain tumors and gives our patients access to the most current clinical trials and treatments.
Brain Tumor Bank
Through the Tissue Donation Program (TDP), headed by Peter Gregersen, MD at The Feinstein Institute for Medical Research, physicians at the Cushing Neuroscience Institute are collaborating with Marc Symons, PhD to create a brain tumor bank. The bank currently contains a substantial collection of malignant and benign tumor samples that have been collected from the Department of Pathology after the samples have been classified as “discards” and available for research purposes. By supporting research initiatives, the Brain Tumor Bank ultimately will improve diagnostics and therapy of people with brain tumors.
Expert care of patients with brain tumors relies on the expertise of neuropathologists who are specifically trained in the diagnosis of brain tumors. Prognosis and management can vary greatly between seemingly subtle differences in diagnosis. Newer techniques of immunohistochemistry and molecular studies such as FISH for 1p and 19q co-deletion play an increasingly important role in diagnosis and prognosis and require special, dedicated expertise for interpretation. Intraoperative pathological consultations, including frozen sections and cytologic preparations, often are used by the surgeon to guide the extent of a resection or to confirm the success of a stereotactic biopsy.
Laboratory for Brain Tumor Biology
Directed by Marc Symons, PhD, current research in the laboratory focuses on two types of brain tumors, medulloblastoma and glioblastoma. Work in the laboratory has shown that two Rho family members, Rac and Cdc42, play critical roles in the invasive behavior of both medulloblastoma and glioblastoma.
The laboratory also studies brain tumor stem cells obtained from brain tumor tissue collected by the Tissue Donation Program. Brain tumor stem cells appear to be critical in tumor development and tumor resistance to radio- and chemotherapy. An outstanding question currently under investigation in the laboratory is whether brain tumor stem cells also contribute to the invasive behavior of brain tumors.
The skilled team of physicians at the Brain Tumor Center coordinates and collaborates with the following Cushing Neuroscience Institute centers to provide a comprehensive multidisciplinary approach to the treatment and care of patients with brain tumors:
For more information on brain cancer treatment, visit The Brain Tumor Center.
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