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Neuropathology, Brain Disorders

The Division of Neuropathology in the Department of Pathology and Lab Medicine at North Shore University Hospital (NSUH) and Long Island Jewish Medical Center (LIJMC) is recognized in Long Island, New York, for its diagnoses and consultations on disorders of the brain and central nervous system. The division provides the tissue diagnosis for all specimens that come from NSUH and LIJMC in conjunction with the Brain Tumor Institute (a multidisciplinary program that focuses on the management of brain tumors) and Cushing Neuroscience Institutes.

Cushing Neuroscience Institutes have organized the neurosciences services into institutes, programs and centers that focus our world-class neuropathologists and resources on the various aspects of neuroscience — the study of the brain, nervous system and spine. Various hospitals throughout the North Shore-LIJ Health System are capable of performing neurosurgery for the treatment of brain disorders such as brain aneurysms, chiari malformation, epilepsy, hydrocephalus, hemorrhage, trauma, spinal disorders, brain tumors. All surgeries which require tissue diagnosis are examined by our very capable neuropathologists, trained at the finest institutes in the United States.

Our neuropathologists provide service to the Childhood Brain and Spinal Cord Tumor Center in the Steven and Alexandra Cohen Children's Medical Center of New York (CCMC) in New Hyde Park. The Childhood Brain and Spinal Cord Tumor Center at CCMC is committed to providing comprehensive, innovative, state-of-the-art care for children diagnosed with tumors of the nervous system. Their multidisciplinary team is dedicated to treating the broad spectrum of benign, malignant, primary and metastatic tumors in young patients whose bodies and brains are still developing.

The Division of Neuropathology provides support to the Movement Disorders Institute, which is dedicated to pushing the frontiers of these neurological conditions through clinical treatment and research. Movement disorders are neurological conditions that can result in spasticity, rigidity, tremor, involuntary movement and ataxia. We provide muscle biopsy reporting with the help of State University of New York, Stony Brook campus. We have a dedicated electron microscopy department at North Shore University Hospital which examines all of our muscle biopsies for disease.

In the 2009-2010 edition of US News and World Report’s “America's Best Hospitals” issue, North Shore-LIJ Medical Center and Staten Island University Hospital were ranked 46th and 47th respectively in the specialty area of Neurology/Neurosurgery. This can be only accomplished by providing a high excellence in neuropathology diagnosis that leads to better management options.

We have the capability to provide the latest tests, like 1p/19q co-deletion and O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation assays for oligodendroglioma tumors and glioblastoma respectively. These assays are not provided in every hospital, and this is great asset to provide molecular pathology testing for the patients who get treated in North Shore-LIJ.

We consult with referring physicians on issues related to patient care and can also offer family members information about the causes or the genetic components of a disease.
 

Experience

Neuropathology has been established in the Department of Pathology for over 30 years. Dr. Peter Farmer, MD, at North Shore University Hospital provided service for both campuses before 2008. Dr. Jian Yi (Jim) Li, MD, PhD, joined North Shore University Hospital in 2008. Dr. Mansoor Nasim, MD, PhD, joined Long Island Jewish Medical Center in 2008. We all provide depth and research capabilities in the diagnosis of CNS disease and brain tumors and are involved in experimental studies of disorders of the brain. The division is working with the following faculty members:

  • Marc Symons, PhD, Investigator, Center for Oncology and Cell Biology; Director, Light Microscopy Facility on medulloblastomas and glioblastomas at the Feinstein Institute of Medical Research
  • Dr. Michael Schulder, Vice Chairman, Department of Neurosurgery; Director, Harvey Cushing Brain Tumor Institute
  • Betty Diamond, MD, Investigator, Head, Center for Autoimmune and Musculoskeletal Disease at Feinstein Institute of Medical Research

Ongoing experience with state-of-the-art research ensures that faculty members remain at the forefront of their fields, with access to the most recent methodologies for diagnosis and continuing experience with many cases of unusual diseases.

Our diagnostic expertise in neuropathology includes such specialties as adult and pediatric brain and spinal cord tumors, cerebrovascular disease, trauma, forensic neuropathology, AIDS and neurodegenerative diseases such as Alzheimer's and Parkinson's.
 

Expertise

Expert Consultation

  • Dr. Peter Farmer (Board Certified neuropathologist) is an experienced neuropathologist. He did his training in neuropathology, trained for clinical neurology and anatomic pathology at Jefferson Medical College Hospital in Philadelphia and did his fellowship in neuropathology at Albert Einstein College of Medicine in New York. He also has vast experience in brain tumors and is a consultant to the Nassau County Medical Examiner for Forensic Neuropathology.
  • Dr. Jian Yi (Jim) Li (Board Certified Neuropathologist) focuses his interests on brain tumors. He completed his residency in anatomic pathology at the University of Oklahoma Health Science Center and a neuropathology fellowship at The Methodist Hospital/M.D. Anderson Cancer Center Neuropathology Fellowship Program. He provides surgical and autopsy neuropathology services.
  • Dr. Mansoor Nasim (Board Certified Neuropathologist) is interested in brain tumors and in neurodegenerative CNS (central nervous system) diseases. Dr. Nasim trained at State University of New York, Downstate Medical Center and has a fellowship in oncologic pathology from Memorial Sloan Kettering Cancer Center in New York. Dr Nasim provides cover for the Cohen Children's Medical Center (CCMC) for Pediatric Neurooncology services with Dr Edelman. He covers the Adult Neuro-Oncopathology services at Long Island Jewish Medical Center.
  • Dr. Morris Edelman is a pediatric pathologist with vast experience in pediatric neuropathology.

Special Capabilities and Services

Our laboratory is fully equipped to perform the special diagnostic tests needed to study tumor and degenerative diseases of the brain, and our nueropathologists have vast experience doing the special stains required for these studies. We are skilled in interpreting stereotactic needle biopsies of brain lesions and can perform in-situ hybridization, immunohistochemistry, light microscopy, immunofluorescence and electron microscopy, as necessary.

IMPORTANT NOTE: Unstained Slides Requirement

Note that all tissue (unstained slides) must be submitted on a plus charged slide. The Immunopathology Laboratory recommends a white plus charged slide that is available from Cardinal Health. The catalogue number for the white plus slide is M6159-6, however, one must specify to the vendor whether to order as one gross (pack of 144 slides) or one case (10 packs per case).

Timely Results

The consultation service aims to respond to requests within 24 hours of the receipt of material. Our neuropathologists personally provide a verbal report to the requesting physician and send the final report by fax. Written reports on post-mortem evaluations are generally provided within two to four weeks. All neuropathologists are available for phone consultations. Pathology material can be returned, if requested. Autopsy specimens are returned promptly upon request, and surgical specimens will be returned promptly after the evaluation and report are completed.

Tests

For Biopsy Specimens and Surgical Neuropathology Consults:
Dr. Jian Yi (Jim) Li, MD, PhD
Division of Neuropathology
Department of Pathology and Lab Medicine
North Shore University Hospital-Long Island Jewish Medical Center
North Shore University Hospital
300 Community Drive
Manhasset, New York 11030
Jli2@nshs.edu
Tel: (516) 562-4160
Fax: (516) 562-4591

Dr. Peter Farmer, MD
Department of Pathology and Lab Medicine
North Shore University Hospital-Long Island Jewish Medical Center
North Shore University Hospital
300 Community Drive
Manhasset, NY, 11030
pfarmer@nshs.edu
Tel: (516) 562-4193
Fax: (516) 562-4591

Dr. Mansoor Nasim, MD, PhD
Surgical Pathology Office
Department of Pathology and Lab Medicine
North Shore University Hospital-Long Island Jewish Medical Center
Long Island Jewish Medical Center
270-05 76th Avenue
New Hyde Park, NY 11040
mnasim@nshs.edu
Tel: (516) 934-0220
Fax: (516) 562-4591
 

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